Clinical Medicine Research

ISSN Online: 2326-9057 ISSN Print: 2326-9049

The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis

Received: Dec. 14, 2021 Accepted: Dec. 31, 2021 Published: Jan. 8, 2022

DOI: 10.11648/j.cmr.20221101.11 Views: Download:


Wan-Yun Lin, School of Dentistry, Hainan Medical University, Haikou, PR China; Department of Dentistry, the First Affiliated Hospital of Hainan Medical University, Haikou, PR China

Lin-Han Wu, School of Dentistry, Hainan Medical University, Haikou, PR China

Xiang-Qiong Chen, Department of Dentistry, the First Affiliated Hospital of Hainan Medical University, Haikou, PR China

Hai-Long Zheng, Department of Dentistry, the First Affiliated Hospital of Hainan Medical University, Haikou, PR China

Zheng-Rou Wang, School of Dentistry, Hainan Medical University, Haikou, PR China

Pin-Xin Zhan, School of Dentistry, Hainan Medical University, Haikou, PR China

Sunchuri Diwas, School of International Education, Hainan Medical University, Haikou, PR China

Zhu-Ling Guo, School of Dentistry, Hainan Medical University, Haikou, PR China; Department of Dentistry, the First Affiliated Hospital of Hainan Medical University, Haikou, PR China


Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.


Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress

To cite this article

Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, Pin-Xin Zhan, Sunchuri Diwas, Zhu-Ling Guo, The Mechanism of Nrf2/ARE Signaling Pathway in Periodontitis with Atherosclerosis, Clinical Medicine Research. Vol. 11, No. 1, 2022, pp. 1-5. doi: 10.11648/j.cmr.20221101.11

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