Clinical Medicine Research

ISSN Online: 2326-9057 ISSN Print: 2326-9049

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Volume 9, Issue 3, May 2020

  • Authors: Na Liu, Yue Liu, Hailin Zhang, Qing Liu

    Abstract: Background and objective: We found that the phenomenon of unreasonable use of gargles is common in clinical practice, which is closely related to the lack of recognition of gargles by dentists. In this study, some dentists in Hebei province of China were investigated to find some problems with their cognition and some reasonable suggestions were put forward. Methods: 600 dentists were chosen by stratified random sampling. A self-designed questionnaire was distributed online to study the knowledge of those dentists with different professional titles on the gargles types, drug resistance, adverse reactions, potential risks and anti-Candida albicans. 576 questionnaires were collected, of which 528 were valid. All valid questionnaires were analyzed by SPSS21.0 software. Results: As for the gargle types, doctors who knew nothing about it accounted for 15.15%. 51.52% of the dentists did not pay attention to the drug resistance. As for the adverse reactions of compound chlorhexidine gargle, doctors who chose "no adverse reactions" and "unclear" accounted for 8.71% and 32.58% respectively. The awareness of "taste change" of primary dentists was lower than that of senior dentists (P<0.05). As for the potential risks of long-term and frequent use of gargles, 87.50% of doctors chose "Oral flora disorder". Doctors who chose other risks were relatively few accounting for 6.44%, and those who chose "unclear" accounted for 12.12%. As for the cognition of gargles against Candida albicans, 7.58% of dentists chose "unclear". Conclusion: The overall cognition of gargles by dentists with different titles is not comprehensive or accurate.

    Received: May 8, 2020 Accepted: May 26, 2020 Published: Jun. 3, 2020

    DOI: 10.11648/j.cmr.20200903.11 View: Downloads:

  • Authors: Anna-Maria Borissovа, Boyana Trifonova, Lilia Dakovska, Evgenia Mihailova, Mircho Vukov

    Abstract: The AIM of our study was to evaluate the association between vitamin D levels and age, body weight before pregnancy and during the screening and the term of pregnancy. MATERIALS AND METHODS: We investigated 547 unselected pregnant Bulgarian women, mean age 30 ± 5 years, median 30 years (18-47 years). The distribution of pregnant women according to their age is as follows: 18-22 y – 33 (6%), 23-27 y – 115 (21%), 28-33 y – 219 (40%), 33-37 y – 128 (23.4%), 38-42 y – 46 (8%), 43-47 y – 6 (1.1%). The allocation according to trimesters of pregnancy was: first trimester - 111 (20.3%), second trimester - 275 (50.4%), and third trimester - 161 (29.3%). In the current study we introduced four categories of 25 (OH) D - <10, 10-20, 20-30 and >30 ng/mL. We evaluated the body weight prior to conception and during pregnancy. The peripheral levels of 25 (OH) D were investigated using a standard assay in a central laboratory on the day of the sampling. RESULTS: We found significant correlation between vitamin D levels and age (P < 0.0001), negative correlation with the BMI prior to conception (P < 0.001) and at the time of the screening (P < 0.0001), but no significant differences among the three trimesters concerning vitamin D levels. CONCLUSIONS: The levels of vitamin D among pregnant Bulgarian women are within the span of mild insufficiency, probably due to the normal BMI before and during the pregnancy. We noticed that with the increase of age, the more mature pregnant women have more responsible behavior and follow the advice of their obstetrician/gynecologist.

    Received: Apr. 25, 2020 Accepted: May 25, 2020 Published: Jun. 4, 2020

    DOI: 10.11648/j.cmr.20200903.12 View: Downloads:

  • Authors: El Hassane Sidibe, Therese Moreira-Diop, Jean-Francois Bach, Baye Assane Diagne, Francis Klotz

    Abstract: Reflexions about immunoradiometric Tsh and Trh test during on Optimal thyroid hormonal therapy (Optimal dosages and overdosages) as Pionnary Auto-immune Primary Hypothyroidism in Dakar [Senegal] gives us A Propose of Whitaker Syndrome Case Report and THYROID GLAND AND ITS PEPTIDES OR ACTUALITYOF GENERAL ENDOCRINOLOGY. Many peptides by their cell molecular metabolism in the thyroid gland are involved: mutations of TSH receptor is linked to hormone resistance with congenital hypothyroidism; a new oroxigenic peptide, Ghrelin is widespread in endocrine tissues; tachykinine is another novel peptide with endocrine paracrine effect. PTTG and FGF-2 are prognostic markers of differentiated cancers; CRIF1 is a novel protein of nucleus interacting with Gadd45 and could negatively regulate cycle cell progression and cell growth; mutations of RET protooncogene is now the best CMT biomarker in the place of calcitonin in addition with CGRP, CGRPβ and Amylin; regulating proteins of CAMP, protein G, Gi alpha 1, MAL proteolipid are identified near immunologic antigens involved in Grave’s disease, autoimmune polyendocrinopathies. These peptides by their diversity of function support the concept of general endocrinology equivalent of medical sciences. Bastenie P. A. classification is a bio-clinical semeiology that could be reviewed by doing the integration of obesity as the incipient stage of epigenetic thyroid turnover of deiodinase realizing an inactive TSH. Thus primary hypothyroidism in an historical-technically point of view can recognize since Bastenie: -1 Atrophic thyroid myxedema with: low T4 and low T3 and High TSH and TRH positive. -2 Mild hypothyroidism where only TSH is High and TRH Test positive. -3 Infra-clinic hypothyroidism where only TRH Test is positive. -4 Compensated thyroiditis where only auto-antibodies are positive. -5 Common obesity where deiodinase turnover is only disturbed. Iodine regulates nutritional metabolism probably via the microbiome. Thyro-diabetes has concerned clinicians. Endocrine disruptors have come to recall us if necessary that thyroid gland is a gate keeper of the environment which in our approach is the testimony of primordial role of mineral iodine in the majority of living beings. Here are the perspectives of General Practitioner of Endocrine Diseases and Clinical Medicine Department.

    Received: Apr. 6, 2020 Accepted: May 8, 2020 Published: Jun. 8, 2020

    DOI: 10.11648/j.cmr.20200903.13 View: Downloads:

  • Authors: Chunjiang Yan, Ye Ye, Ruifeng Zeng, Xiaoxin Wu, Guorong Liang, Huanmei Li

    Abstract: Hemophilia is a set of hereditary hemorrhagic disorders of coagulation-dysfunction that can cause repeated bleeding in various tissues and organs. And the patient can be disabled due to bleeding from bones, joints, and soft tissue, or die due to splenic rupture or intracranial bleeding. So it is crucial to detect the site of bleeding in hemophilia patients quickly. Spontaneous spinal canal hematoma is a rare complication of hemophilia, with less than 50 cases reported to date. It can be easily missed and cause serious harm to patients. Hematoma, if untreated, causes irreversible nerve damage by compression of the spinal cord. Early recognition and treatment are most useful to prevent spontaneous spinal canal hematoma. We describe the case of a 21-year-old man with severe lumbago for two days, who had hemophilia A for a decade. The patient was diagnosed with spinal subdural hematoma by magnetic resonance imaging (MRI) after ruling out other causes of lumbago and treated with drugs by a neurologist. The hematoma showed absorption by MRI after six months. In conclusion, spontaneous spinal canal hematoma is a severe complication of hemophilia, which is often missed. This successful case confirms the importance of early diagnosis and treatment of spontaneous spinal canal hematoma. We hope to increase the clinicians’ vigilance of this disease.

    Received: May 22, 2020 Accepted: Jun. 12, 2020 Published: Jun. 20, 2020

    DOI: 10.11648/j.cmr.20200903.14 View: Downloads:

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