Clinical Medicine Research

ISSN Online: 2326-9057 ISSN Print: 2326-9049

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Volume 9, Issue 1, January 2020

  • Authors: Peng Qian, Li Wenxia, Ma Jun, Wang Lijun, Liu Weiwei

    Abstract: Investigate the relationship between anxiety, depression and social support of caregivers of mentally retarded children, and provide further reference for their positive development. The Social Support Rating Scale and General Hospital Anxiety and Depression Scale were conducted among 111 caregivers of mentally retarded children in three special education institutions in a district of Chongqing by cluster sampling. SPSS22.0. was used to statistical analysis. The incidences of anxiety and depression in caregivers of mentally retarded children were 52.3% and 53.2% respectively. Caregivers of mentally retarded children in non-anxiety group and non-depression group scored significantly higher in subjective support, objective support, and total social support than those in obvious anxiety group and obvious depression group. Social support (γ=-0.392, γ=-0.390) and subjective support (γ=-0.335, γ=-0.325), objective support (γ=-0.306, γ=-0.321) and support utilization (γ=-0.235, γ=-0.224) for caregivers of mentally retarded children were negatively correlated with anxiety and depression. Multiple linear regression analysis showed that subjective support and objective support had negative effects on anxiety and depression. The anxiety, depression and social support of parents of mentally retarded children will interact each other. And providing diversified and service-oriented social support is conducive to alleviate their anxiety and depression, then promote their positive development.

    Received: Jan. 2, 2020 Accepted: Jan. 18, 2020 Published: Jan. 31, 2020

    DOI: 10.11648/j.cmr.20200901.11 View: Downloads:

  • Authors: Andreea Wagner, Elena Preoteasa, Cristina Teodora Preoteasa

    Abstract: Quality of life is an important outcome to accomplish, representing the final goal for the management of all general diseases. Diabetes mellitus is a chronic general disease with a high prevalence all over the world, mainly in adults and elderly. Patients with diabetes type 2 seem to have a worst quality of life in comparison to healthy ones. The objective of this study was to assess the oral health-related quality of diabetic type 2 patients in relation to general health status, medication and demographic factors. Methods: One hundred and thirty-five patients, 68 type 2 DM and 67 nondiabetic were interviewed. Health-related quality of life was evaluated using the GOHAI questionnaire and related to general health, clinical and sociodemographic variables. Statistical analyses were determined using SPSS 18, t-test, ANOVA test, Pearson’s correlation coefficient for quantitative variables and chi-test for qualitative variables. P value < 0.05 was considered significant. Results: Among the studied population, the mean age was 66 for diabetic patients and 69 for the nondiabetic ones. Females, from rural environment, obese, with more than 7% HbA1C levels reported worse quality of life. Smoking din not influenced significantly the results. Type 2 diabetic patients, with insulin therapy, with more than 10 years duration of disease, with other comorbidity present had lower results in all the three quality of life domains. Conclusion: We found that the quality of life in diabetic type 2 patients was lower in all the domains (psychological, physical, pain) in comparison with nondiabetic persons, but with little difference between study groups.

    Received: Jan. 12, 2020 Accepted: Feb. 3, 2020 Published: Feb. 13, 2020

    DOI: 10.11648/j.cmr.20200901.12 View: Downloads:

  • Authors: Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, Xing An, Ju Hua Gong, Wang Huan

    Abstract: The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.

    Received: Jan. 14, 2020 Accepted: Feb. 7, 2020 Published: Feb. 14, 2020

    DOI: 10.11648/j.cmr.20200901.13 View: Downloads:

  • Authors: Silas Anayochukwu Ufelle, Kenechukwu Chibuike Onyekwelu, Peter Uwadiegwu Achukwu, Augustine Chidi Ndubisi, Richard Chukwunonye Ezeh, Lorreta Nwakaego Nwokolo

    Abstract: Tuberculosis (TB) is a disease caused by bacteria called Mycobacterium tuberculosis. We aimed to evaluate the complete blood count (CBC) and erythrocyte sedimentation rate (ESR) of confirmed extra-pulmonary tuberculosis (EPTB) patients attending clinic at the University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu. A total of 90 confirmed extra-pulmonary tuberculosis patients consisting of male (n = 38) and female (n = 52), aged 15 to 60 years attending clinic participated in this study. CBC and ESR were analysed using Haematological Auto Analyzer and Westergren method respectively. Haemoglobin and haematocrit values across the three age groups (15-30, 31-45, 46-60 years) were significantly lower (p < 0.05) than the control value in both male and female extra-pulmonary tuberculosis patients. Erythrocyte sedimentation rate, white blood count, platelet and neutrophil values across the three were significantly higher (p < 0.05) than the control values in both male and female extra-pulmonary tuberculosis patients. Extra-pulmonary tuberculosis was observed more in females than the males and was relatively higher in older patients (above 46 years) than younger patients (below 46 years). This study was able to show that different haematological parameters such as haemoglobin, haematocrit, Erythrocyte sedimentation rate, white blood count, platelet and neutrophil could serve as hallmark and help in early diagnosis of extra-pulmonary tuberculosis.

    Received: Aug. 11, 2019 Accepted: Oct. 23, 2019 Published: Feb. 18, 2020

    DOI: 10.11648/j.cmr.20200901.14 View: Downloads:

  • Authors: Andreas Werner, Ulrich Kreutzmann, Stephanie Glowka, Cynthia Schinkel

    Abstract: Remotely piloted aircraft (RPA; also called drones) constitute a new dimension in aviation. In the past, the military used RPAs extensively in the conflicts in Iraq and Afghanistan. Meanwhile, they are employed worldwide, which illustrates the new way of future complementary military warfare. It is well known that military personnel develops mental health disorders (MHD) during their military services or after deployments, including military pilots or fighting personnel (15.9 per 1,000 person-years). Despite the assumption that operators of drones compared to pilots are not vulnerable to MHD, because they are not physically involved and far away from combat operations and the battlefield, it becomes apparent that there is evidence that they are affected in the same way. During the last years, typical symptoms of PTSD occurred in such individuals and resulted in a severe disturbance of health (25.0 per 1,000 person-years). Currently, to our best knowledge, only in the U.S. Air Force (USAF) RPA operators participate directly in the act of war also using destructive weapons. Especially in this population, increasing and high levels of psychological stress, fatigue, and rates of MH diagnoses were found, without significant difference in the rates of post-traumatic stress disorder, depressive disorders, and anxiety disorders between RPA operators and traditional pilots. The German Air Force has been using drones up to now exclusively for reconnaissance. According to empiric observation, the development of MHD among German RPAs operators was not observed, but it has to be assumed that we will also find these illnesses if we proceed with this technology. Hence, military policymakers and clinicians should be highly sensitive to the fact that RPA operators also have a high probability of developing mental health disorders, particularly when using remotely piloted aircraft as weapons.

    Received: Aug. 29, 2019 Accepted: Nov. 22, 2019 Published: Feb. 18, 2020

    DOI: 10.11648/j.cmr.20200901.15 View: Downloads:

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