Clinical Medicine Research

ISSN Online: 2326-9057 ISSN Print: 2326-9049

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Volume 5, Issue 3, May 2016

  • Authors: Jing Wang, Min Chen, Jiang Du

    Abstract: By a long term follow-up, we evaluated the effects of conservative treatment for refracture of cemented vertebrae after percutaneous vertebroplasty (PVP). 12 patients of 324 patients who underwent PVP from January 2012 to August 2014, with back pain, were confirmed refracture in cemented vertebrae. 7 patients got conservative treatment: the usage of analgesics, osteoporosis medication, brace and physical therapy. Visual analogue seale (VAS) and Oswestry disability index (ODI) were evaluated at 7 days, 1, 3 and 12 months after treatment. Patients were followed up for 21.3 ± 11.2 months. Compared with that before treatment, VAS and ODI scores were significantly decreased after treatment (P < 0.05). VAS and ODI scores were also decreased significantly among 7 days, 1 and 3 months after treatment (P < 0.05). No remarkable difference was found between 3 and 12 month (P > 0.05). Further, there were no complications happened, such as leg phlebothrombosis, decubitus and hypostatic pneumonia. Thus, the results of our conservative treatment were optimal. Accordingly, the ratio of refracture in cemented vertebrae after PVP is low, but it is critical for back pain after PVP which should be pay enough attention for clinicians. Conservative treatment can relieve pain and improve spine function, without obvious complications.

    Received: Mar. 15, 2016 Accepted: Apr. 5, 2016 Published: Apr. 26, 2016

    DOI: 10.11648/j.cmr.20160503.11 View: Downloads:

  • Author: Albert Pesha

    Abstract: Benign prostatic hypertrophy can be treated by several therapeutic options including medical and surgical techniques. Among the surgical options, transurethral resection has a crucial role. Transurethral resection of the prostate (TURP) remains the standard surgical treatment for benign prostatic hypertrophy (BPH). This technique was the first minimally invasive procedure of the modern surgical practice remaining the most commonly procedure. During 2010-2015, 324 patients were enrolled in our study, recording all postoperative complications. Our paper emphasizes all the theoretical aspects of TURP’s complications comparing to our data.

    Received: Mar. 24, 2016 Accepted: Apr. 18, 2016 Published: Apr. 28, 2016

    DOI: 10.11648/j.cmr.20160503.12 View: Downloads:

  • Authors: Oznur Koylu, Mehmet Yortanli

    Abstract: Background: There are many biomarkers defined for systemic inflammation and sepsis. Cholinesterase and its biological role is not entirely known but in recent studies, it was seen that cholinesterase levels had a diagnostic value in predicting both sepsis and mortality. Objective: The purpose of this study is to establish the role of cholinesterase activity as a biomarker in the early diagnosis and treatment planning of sepsis which is an uncontrolled inflammatory response of the host to an infection. Materials and Method: This is a controlled, observational, and prospective clinical study and has been carried out on patients admitted to the intensive care unit with sepsis. The demographic features, the medical history and vital findings of the patients were recorded. According to the intensive care monitoring and treatment procedures, the complete blood count test, urine test and routine biochemical assessments particularly the CRP, procalcitonin and blood gasses tests were performed and the serum cholinesterase activity was assessed. The data was digitalized and then analyzed using the SPSS 15.0 software package. Results: The cholinesterase levels detected in the patient group were lower than the cholinesterase levels of the control group and there was a significant difference between the groups (p< 0.001). A statistically significant association was detected between the severity of sepsis and the cholinesterase levels of the patients. There was also a statistical relationship between the cholinesterase levels and being connected to mechanical ventilation and the use of vasopressors (p<0.05). There was a significant association between mortality and cholinesterase levels (p= 0.009). As the cholinesterase activity decreased the mortality rate increased. As a result of the ROC analyses performed to establish the diagnostic value of the patients' cholinesterase levels in predicting sepsis and morality it was seen that cholinesterase levels had a diagnostic value in predicting both sepsis and mortality. Conclusions: We believe that the cholinesterase activity investigated in our study is an extremely useful biomarker in the diagnosis and prognosis prediction of the sepsis syndrome that progresses with systemic inflammation.

    Received: Mar. 31, 2016 Accepted: Apr. 14, 2016 Published: Apr. 28, 2016

    DOI: 10.11648/j.cmr.20160503.13 View: Downloads:

  • Authors: Ale Alexander Femi, Achinge Godwin Ior, Peter Solomon Danjuma, Shitta Andrew Haruna, Misauno Michael Ayedima

    Abstract: Bleeding from oesophageal varices is the most dreaded complication of chronic liver disease and is associated with high mortality. Endoscopic variceal ligation is one of the more recent effective treatment modalities. This study was aimed at evaluating our experience with endoscopic variceal ligation with a view to stressing the safety associated with the procedure. A prospective study of consecutive patients presenting to the Jos University Teaching Hospital and FOMAS hospital endoscopic units was conducted over a 6 year period. A total of 199 sessions of endoscopic sessions were carried out on 83 patients with different grades of varices. There were 68 males and 15 females (M:F = 4.5:1). The mean age of the study population was 48 +/- 7.4 years with age range of 17 to 63 years. The number of sessions of banding required for variceal obliteration in this study varied from 43 (51.8%) who had 3 sessions of banding, 30 (36.1%) who had 2 sessions and 10 (12.0%) that had a single session of variceal band ligation. All patients were placed on Propanolol tablets. There were no recorded episodes of procedure related bleeding, significant re-bleeding, post-procedure retrosternal pain, stricture or ulceration in this study, attesting to the safety of endoscopic variceal ligation.

    Received: Apr. 3, 2016 Accepted: Apr. 20, 2016 Published: May 3, 2016

    DOI: 10.11648/j.cmr.20160503.14 View: Downloads:

  • Authors: Galiya Ibadullayeva, Volodimir Grudko, Аssyl Boshkayeva, Zuriyadda Sakipova, Talgat Dzalgasbayev, Gulbaram Ustenova, Kaldanay Kozhanova, Nazerke Uristemkhankyzy, Eduard Bissenbaev, Nurgan Tussupova, Sholpan Mulkibayeva, Ilyas Tazabekov

    Abstract: We have received extracts from air-dried raw material of medicinal plants Acorus Сalamus and Calendula officinalis in the mode of low-temperature subcritical extraction by liquefied carbon dioxide (CO2), the output of which made 0.7 to 0.8%. The content of camphor and β-pinene in 1 g of Acorus Сalamus extract is not less than 0.1%; the content of carotenoids in terms of β-carotene in 1 g of the extract of Calendula officinalis - not less than 0.35 mg/g. We have developed combined pills "Exkair" of the following composition: thick extract of Acorus Сalamus rhizomes (0.009 g), thick extract of flowers of Calendula officinalis (0.005 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.015 g). The pills underwent a number of physico-chemical testings according to the requirements of the project PAND (Provisional Analytic Normative Document). The content of active substances (carotenoids) in 1 tablet is 0.782 mg, camphor and pinene 0.97 mg.

    Received: Feb. 20, 2016 Accepted: Apr. 25, 2016 Published: May 13, 2016

    DOI: 10.11648/j.cmr.20160503.15 View: Downloads:

  • Authors: Аssyl Boshkayeva, Roza Omarova, Assel Kozhamzharovа, Aigul Uvaganova, Gulzira Aitzhanova, Bolat Zhanturiyev, Manas Omurzakov, Daniyar Abdambaev

    Abstract: Quantum-chemical study of molecular objects, such as organic amine systems protonated inorganic acids, it becomes important not only to establish the characteristics of the geometric and electronic structure of the starting amides and their complexes, but also allows you to set a semi-empirical model of the protonation process by identifying patterns of change in the basic parameters of the structure. Comparative analysis of the characteristics of spatial and electronic structure model systems-substituted-acetamide inorganic acids (HF, HCl, H2SO4) on the basis of quantum-chemical calculations by PM3 bond lengths, the charge characteristics of the ionization potential of the dipole moments and led to the following conclusions: - In systems-alkyl derivatives acetamide hydrofluoric acid is a significant change in the bond lengths and values of the electronic characteristics is not observed; - In systems alkyls acetamide-HCl, H2SO4 lengths of C=O and C-N depend upon the nature of the inorganic acid and the change in the electronic characteristics during protonation independent of acid strength and due to the characteristics of their spatial and electronic structure and nature of the alkyl substituents in amino acetamide group.

    Received: Feb. 20, 2016 Accepted: Mar. 10, 2016 Published: May 20, 2016

    DOI: 10.11648/j.cmr.20160503.16 View: Downloads:

  • Authors: Bassi Amos Paul, Idoko Lucy, Dibigbo-Ibeaji Ndudi Mary, Adeniyi Olusegun Godwin, Ramyil Mamzhi-Crown Seljul, Ogundeko Timothy Olugbenga, Pisagih James Kurgnan, Offiah Valeria Nneka, Olorunfunmi Joshua Seye, Amuta Wilson Ehi, Alu Vivian Ojoma, Ajala Ese Kate, Olorundare Olufunke Olufunmilola

    Abstract: In developing countries such as Nigeria, anaemia in pregnancy is thought to be one of the most common problem affecting pregnant women accounting for a significant level of maternal morbidity and mortality. This study was carried out to determine the prevalence of anaemia in pregnancy among women visiting Antenatal Clinic (ANC) in Bingham University Teaching Hospital (BHUTH). This is a cross sectional descriptive study conducted from August to September, 2015 on two hundred and thirty seven (237) women. A semi–structured interviewer administered questionnaire was used to obtain socio-demographic, obstetrics, and nutritional information from the respondent pregnant women who consented at each antenatal clinic days (Mondays and Thursdays). Packed cell volume was used to assess the level of anaemia in accordance to WHO guide lines. The prevalence of anaemia in pregnancy was found to be 43.5%, amongst all women who were anaemic, 83%, 8.7% and 2% were found to have mild, moderate and severe anaemia respectively. However, 0.9%, 35%, 52% of these women were found to be in their first, second and third trimesters respectively. 61% were multi-parous women (para 2-4); 24.3% women had only two antenatal clinic visits, 66.2% women were within the age group of 34–39 years; 89.3% women had been taking balanced diet, while 89.3% women were on their routine drugs; 66.0% women used insecticide treated mosquito net; 66.0% women had taken anti-malarial prophylaxis. Reduced ANC visits and increasing age where significant factors associated with anaemia in pregnancy. Prevalence of anaemia amongst pregnant women in BHUTH was 43.5%. The most common type of anaemia in this study is mild anaemia. However, the prevalence of anaemia was found to predominate amongst women in their third trimester. Increased maternal age and reduced number of antenatal care visits were statistically significant factors to be associated with anaemia in pregnancy.

    Received: May 6, 2016 Accepted: May 18, 2016 Published: May 30, 2016

    DOI: 10.11648/j.cmr.20160503.17 View: Downloads:

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