Clinical Medicine Research

ISSN Online: 2326-9057 ISSN Print: 2326-9049

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Volume 5, Issue 2, March 2016

  • Authors: Olivier Pancha Mbouemboue, Diallo Cellou, Marcel Tangyi Tamanji, Chantal Blakga, Armel Herve Nwabo Kamdje, Jacques Olivier Ngoufack, Andre Youmbi

    Abstract: Background: In sub-Saharan Africa, hypertensive disorders in pregnancy remain a major call for concern owing to their increasing incidence, gravity and associated complications. In Cameroon, the epidemiological reality of hypertensive disorders in pregnancy remains unknown in the majority of regions. Objective: This study aimed to identify the determinants of hypertensive disorders among pregnant women in a hospital milieu in Ngaoundere town. Methods: A cross-sectional study was carried out at the Ngaoundere Regional Hospital, the reference hospital facility of the Adamawa Region of Cameroon from May to June 2014. Results: In total, 160 pregnant women were examined during the period of study, among which 75 recorded a high blood pressure thus fulfilling our inclusion criteria. Age (P=0.013), previous twin pregnancy (P=0.013) and preeclampsia (P=0.013) were found to be significantly predictive of chronic hypertension. Religion (P=0.004) and multiparity (P=0.001) were identified as significant independent predictive risk factors of preeclampsia, History of preeclampsia (P=0.025) was identified as predictive risk factor for superimposed preeclampsia. Conclusion: Independent predisposing factors associated with hypertensive disorders in pregnancy in our milieu, which include advanced age, the notion of preeclampsia and history of twin pregnancy for chronic hypertension, parity and religion for preeclampsia, and history of preeclampsia for superimposed preeclampsia.

    Received: Jan. 10, 2016 Accepted: Feb. 12, 2016 Published: Apr. 26, 2016

    DOI: 10.11648/j.cmr.20160502.11 View: Downloads:

  • Authors: Urziya Alimova, Аssyl Boshkayeva, Nurgan Tussupova, Roza Omarova, Galiya Ibadullayeva, Zuriyadda Sakipova, Yernar Dzhadranov, Kurakbai Zharimbetov, Eduard Bissenbaev, Ubaidulla Datkhayev

    Abstract: The raised standard requirements regulated by the State Pharmacopoeia and the Analytical Normative Document (AND) are imposed to quality of the medicines applied in medical practice of the Republic of Kazakhstan. One of the main requirements imposed to quality of medicines is stability. The specification of test of stability of the tablets "Exkair" reflecting an assessment of physical and chemical properties of tablets and the list of indicators of quality according to requirements of the project of the AND is developed for expression of this concept. Determination of stability of tablets was carried out in the mode (long-term/real time testing) of long-term tests: temperature of natural storage - 25±2°C, relative humidity - (60±5)%. The indicators of quality of tablets included in the specification of stability on HP "Exkair" with reduction of test conditions and techniques of definition are presented. Results of test of stability of tablets confirm structure of a preparation: active substances - extract from the rhizomes of Acorus Calamus (0.009 g), extract of flowers of the Calendula officinalis (0.003 g); auxiliary substances - ascorbic acid (0.005 g), calcium stearate (0.006 g), sugar powder (0.517 g), aerosil (0.0015 g). On the basis of these test the assessment of quality of tablets with establishment of numerical values of parameters including period of storage is carried out. Period of storage of medicine established experimentally by the method of long-term storage under natural conditions within 2 years in packing regulated by the draft of the Analytical Normative Document (AND). Initial period of storage of the tablets "Exkair" makes 2 years. In this research period of storage of ready medicine was determined irrespective of expiration dates of the main substance (extract from the rhizomes of Acorus Calamus and extract of flowers of the Calendula officinalis).

    Received: Feb. 16, 2016 Accepted: Apr. 13, 2016 Published: Apr. 26, 2016

    DOI: 10.11648/j.cmr.20160502.12 View: Downloads:

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