Clinical Medicine Research

ISSN Online: 2326-9057 ISSN Print: 2326-9049

  •  
  •  
  •  
About the Journal

ISSN Online: 2326-9057 ISSN Print: 2326-9049

Current Issue: Vol. 11, Issue 1, January 2022

Frequency: Bimonthly

Clinical Medicine Research (http://www.cmder.org) is an open access peer-reviewed journal that publishes high-quality papers from researchers all around the world.

Read More
Special Issue

The list of the ongoing Special Issue(s) is shown below. Authors can find the most suitable Special Issue for their papers.

Epigenetic Modification of Essential Hypertension Gene and Gene Therapy

Lead Guest Editor: Zhi xiong Zhong

Submission Deadline: Dec. 1, 2022

Paraneoplastic Limbic Encephalitis

Lead Guest Editor: Maria Sofia Cotelli

Submission Deadline: Oct. 31, 2022

Drug-induced Neurologic Disorders

Lead Guest Editor: Filippo Manelli

Submission Deadline: Oct. 31, 2022

Read More

Proposing a special issue allows you to become the lead guest editor, and the joined guest editors can then manage the peer review process and compile accepted articles with you. If a special issue is organized successfully, it can be a unique and valuable reference source for every researcher interested in that area.

Propose a Special Issue
Latest Articles
  • Authors: Wan-Yun Lin, Lin-Han Wu, Xiang-Qiong Chen, Hai-Long Zheng, Zheng-Rou Wang, Pin-Xin Zhan, Sunchuri Diwas, Zhu-Ling Guo

    Abstract: Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.

    Received: Dec. 14, 2021 Accepted: Dec. 31, 2021 Published: Jan. 8, 2022

    DOI: 10.11648/j.cmr.20221101.11 View: Downloads:

  • Authors: Wanting Li, Jinying Wang, Zhuoming Chen

    Abstract: As a kind of congenital myopathy (CM), central core disease (CCD) is mainly characterized by low muscle tension, slow progressive or static proximal limb weakness. CM can be characterized by no symptoms to be unable to walk independently in the clinic, pathological changes can be manifested as only significant type 1 muscle fiber dominant type to typical central axial space structure, and there are also many genetic ways. Duchenne muscular dystrophy (DMD) is a common congenital myopathy, which is mainly manifested in the typical pathological changes of early progressive myasthenia and muscular dystrophy. Both CCD and DMD show similar clinical symptoms and their serum creatine kinase can be increased, which is often difficult to distinguish them through clinical characterization and laboratory examination. In this study, we report the clinical and genetic characteristics of two patients with progressive muscle weakness with elevated creatine kinase. They are the product of a first-cousin marriage and seek medical treatment due to asymptotic walking difficulties, muscle atrophy, joint contracture, scoliosis, and elevated creatine kinase levels. It was previously suspected as Duchenne muscular dystrophy. After that, the patient's DNA was sequenced by whole-exome sequencing (WES), and all coding regions were investigated. It was found that a new heterozygous missense mutation c.5092g > A in the RYR1 gene. Similar mutations have not been reported in the literature before. Bioinformatics software predicts that they have the possibility of pathogenesis, which is highly correlated with CCD. The purpose of this case is to report a new heterozygous mutation of the RYR1 gene, summarize the similarities and differences of clinical manifestations, genetic characteristics, and pathological changes of CCD and DMD, and provide a new idea for its differential diagnosis.

    Received: Nov. 28, 2021 Accepted: Dec. 14, 2021 Published: Dec. 29, 2021

    DOI: 10.11648/j.cmr.20211006.20 View: Downloads:

Read More
Editorial Members
  • Ravinder Gaddam

    Department of Internal Medicine, The University of Iowa, Iowa City, USA

  • Somayeh Rostamian

    Department of Medicine, National Heart and Lung Institute, Imperial College London, London, UK

  • Yuancheng Zhang

    Department of Spine Surgery, University Hospital of Basel, Basel, Switzerland

Read More
Peer Reviewers
  • Niraj Khatri Sapkota

    Department of Physiology, Chitwan Medical College, Tribhuvan University, Chitwan, Bharatpur, Nepal

Read More